BDBM50365264 CHEMBL1738926
SMILES Cc1nnc2[C@H](NC(=O)OCc3ccccc3)N=C(c3ccccc3)c3ccccc3-n12
InChI Key InChIKey=TUWDLUFFAHHNEF-QHCPKHFHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50365264
Affinity DataIC50: 28.4nMAssay Description:Displacement of tetra-acetylated H4 peptide from human Brd3 bromodomain BD12 after 1 hr by FRET analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 28.4nMAssay Description:Displacement of acetylated histone peptide from BRD3-BD1,2 by FRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 46nMAssay Description:Binding affinity to BRD3-BD1,2 by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataKd: 19nMAssay Description:Binding affinity to His6-tagged BRD3 expressed in Escherichia coli by isothermal colorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of His6-tagged BRD3 expressed in Escherichia coli assessed as inhibition of binding to SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHGSGSK-bio...More data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of His6-tagged BRD3 expressed in Escherichia coli after 60 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
Affinity DataIC50: 631nMAssay Description:Binding affinity to His6-tagged BRD3 (unknown origin) after 60 mins by fluorescence anisotropy binding AssayMore data for this Ligand-Target Pair
Affinity DataKd: 19nMAssay Description:Binding affinity to N-terminal portion of human Brd3 containing bromodomain BD12 expressed in Escherichia coli by isothermal titration calorimetric a...More data for this Ligand-Target Pair